Molecular Pathways Linking High-Fat Diet and PM_2.5 Exposure to Metabolically Abnormal Obesity: A Systematic Review and Meta-Analysis.

ABSTRACT: Obesity, influenced by environmental pollutants, can lead to complex metabolic disruptions. This systematic review and meta-analysis examined the molecular mechanisms underlying metabolically abnormal obesity caused by exposure to a high-fat diet (HFD) and fine particulate matter (PM_2.5). Following the PRISMA guidelines, articles from 2019 to 2024 were gathered from Scopus, Web of Science, and PubMed, and a random-effects meta-analysis was performed, along with subgroup analyses and pathway enrichment analyses. This study was registered in the Open Science Framework. Thirty-three articles, mainly case-control studies and murine models, were reviewed, and they revealed that combined exposure to HFD and PM_2.5 resulted in the greatest weight gain (82.835 g, p = 0.

SUBMITTER: Lobato S 

PROVIDER: S-EPMC11674716 | biostudies-literature | 2024 Dec

REPOSITORIES: biostudies-literature