Concave Magnetic-Responsive Hydrogel Discs for Enhanced Bioassays.

ABSTRACT: Receptor-based biosensors often suffer from slow analyte diffusion, leading to extended assay times. Moreover, existing methods to enhance diffusion can be complex and costly. In response to this challenge, we presented a rapid and cost-effective technique for fabricating concave magnetic-responsive hydrogel discs (CMDs) by straightforward pipetting directly onto microscope glass slides. This approach enables immediate preparation and customization of hydrogel properties such as porosity, magnetic responsiveness, and embedded particles and is adaptable for use with microarray printers. The concave design increased the surface area by 43% compared to conventional hemispherical hydrogels, enhancing diffusion rates and accelerating reactions. By incorporating superparamagnetic particles, the

SUBMITTER: Ghaffarzadeh Bakhshayesh A 

PROVIDER: S-EPMC11674732 | biostudies-literature | 2024 Dec

REPOSITORIES: biostudies-literature