Hierarchical double-layer microneedles accomplish multicenter skin regeneration in diabetic full-thickness wounds.

ABSTRACT:

Introduction

Managing large chronic wounds presents significant challenges because of inadequate donor sites, infection, and lack of structural support from dermal substitutes. Hydrogels are extensively used in various forms to promote chronic wound healing and provide a three-dimensional spatial structure, through growth factors or cell transport.

Objectives

We present a novel multicenter regenerative model that is capable of regenerating and merging simultaneously to form a complete layer of skin. This method significantly reduces wound healing time compared to the traditional centripetal healing model. We believe that our model can improve clinical outcomes and pave the way for further research into regenerative medicine.

Methods

We prepared a novel multi-island do

SUBMITTER: Huang X 

PROVIDER: S-EPMC11674785 | biostudies-literature | 2024 Dec

REPOSITORIES: biostudies-literature