HMGB1 promotes chemoresistance in small cell lung cancer by inducing PARP1-related nucleophagy.

ABSTRACT:

Introduction

Small cell lung cancer (SCLC) is prone to chemoresistance, which is closely related to genome homeostasis-related processes, such as DNA damage and repair. Nucleophagy is the elimination of specific nuclear substances by cells themselves and is responsible for maintaining genome and chromosome stability. However, the roles of nucleophagy in tumour chemoresistance have not been investigated.

Objectives

The aim of this work was to elucidate the mechanism of chemoresistance in SCLC and reverse this chemoresistance.

Methods

RNA-seq data from SCLC cohorts, chemosensitive SCLC cells and the corresponding chemoresistant cells were used to discover genes associated with chemoresistance and patient prognosis. In vitro and in vivo experiments were performed to veri

SUBMITTER: Shen W 

PROVIDER: S-EPMC11674788 | biostudies-literature | 2024 Dec

REPOSITORIES: biostudies-literature