Microdissection of Distinct Morphological Regions Within Uveal Melanomas Identifies Novel Drug Targets.

ABSTRACT: Background/Objectives: Uveal melanomas (UMs) are rare but often deadly malignancies that urgently require viable treatment options. UMs often exhibit tumour heterogeneity, with macroscopic and microscopic differences in morphology between different regions of the same tumour. However, to date, the clinical significance of this and how it may help guide personalised therapy have not been realised. Methods: Using targeted DNA and RNA sequencing of a small case series of large, high-risk primary UMs, we explored whether morphologically distinct regions of the same tumour were associated with distinct molecular profiles. Results: In four of the seven tumours analysed, we detected different sets of genetic variants following the separate analysis of microdissected melanotic

SUBMITTER: Toumi E 

PROVIDER: S-EPMC11674814 | biostudies-literature | 2024 Dec

REPOSITORIES: biostudies-literature