Molecular Markers in Embryo Non-Development: Analysis of Gene Expressions (<i>Ki-67</i>, <i>hTERT</i>, <i>HIF-1α</i>) in Spent Embryo Culture Medium.

ABSTRACT: An embryo culture medium is a specialized set of ambient conditions, technological equipment, and nutrients that embryos require to grow properly. We aimed to investigate the Ki-67, hTERT, and HIF-1α gene expression differences between developing and non-developing embryos in spent embryo culture medium. Ki-67, hTERT, and HIF-1α gene expressions were determined from the spent embryo culture medium containing developing and non-developing embryos of 20 normoresponder patients admitted to the Bahçeci Umut IVF Center. An increase in hTERT gene expression (p < 0.05) and a decrease in HIF-1α gene expression (p < 0.001) were observed in mediums of developing compared to the non-developing embryos. No difference was observed in

SUBMITTER: Kılıc NO 

PROVIDER: S-EPMC11674905 | biostudies-literature | 2024 Dec

REPOSITORIES: biostudies-literature