Gamma frequency connectivity in frontostriatal networks associated with social preference is reduced with traumatic brain injury.

ABSTRACT: Among the myriad of complications associated with traumatic brain injury (TBI), impairments in social behaviors and cognition have emerged as a significant area of concern. Animal models of social behavior are necessary to explore the underlying brain mechanisms contributing to chronic social impairments following brain injury. Here, we utilize large-scale brain recordings of local field potentials to identify neural signatures linked with social preference deficits following frontal brain injury. We used a controlled cortical impact model of TBI to create a severe bilateral injury centered on the prefrontal cortex. Behavior (social preference and locomotion) and brain activity (power and coherence) during a three-chamber social preference task were compared between sham and injured animal

SUBMITTER: Salimi M 

PROVIDER: S-EPMC11675011 | biostudies-literature | 2024

REPOSITORIES: biostudies-literature