Structural Characterization and In Vitro and In Silico Studies on the Anti-α-Glucosidase Activity of Anacardic Acids from Anacardium occidentale.

ABSTRACT: The growing focus on sustainable use of natural resources has brought attention to cashew nut shell liquid (CNSL), a by-product rich in anacardic acids (AAs) with potential applications in diabetes treatment. In this study, three different AAs from CNSL, monoene (15:1, AAn1), diene (15:2, AAn2), and triene (15:3, AAn3), and a mixture of the three (mix) were evaluated as α-glucosidase inhibitors. The samples were characterized by combining 1D and 2D NMR spectroscopy, along with ESI-MS. In vitro assays revealed that AAn1 had the strongest inhibitory effect (IC₅₀ = 1.78 ± 0.08 μg mL^-1), followed by AAn2 (1.99 ± 0.76 μg mL^-1), AAn3 (3.31 ± 0.03 μg mL^-1), and the mixture (3.72 ± 2.11 μg mL^-1). All AAs significantly outperformed acarb

SUBMITTER: Silva APMD 

PROVIDER: S-EPMC11675133 | biostudies-literature | 2024 Dec

REPOSITORIES: biostudies-literature