Magnetically Induced Anisotropic Microstructures on Polyethylene Glycol Hydrogel Facilitate BMSC Alignment and Osteogenic Differentiation.

ABSTRACT: Many tissues exhibit structural anisotropy, which imparts orientation-specific properties and functions. However, recapitulating the cellular patterns found in anisotropic tissues presents a remarkable challenge, particularly when using soft and wet hydrogels. Herein, we develop self-assembled anisotropic magnetic Fe₃O₄ micropatterns on polyethylene glycol hydrogels utilizing dipole-dipole interactions. Under the influence of a static magnetic field, Fe₃O₄ nanoparticles align into highly ordered structures with a height of 400-600 nm and a width of 8-10 μm. Furthermore, our layer-by-layer assembly technique enables the creation of oriented micropatterns with varying densities and heights, which can be further manipulated to form three-dimensional

SUBMITTER: Zhang H 

PROVIDER: S-EPMC11675349 | biostudies-literature | 2024 Dec

REPOSITORIES: biostudies-literature