Biliverdinuria Caused by Exonic <i>BLVRA</i> Deletions in Two Dogs with Green Urine.

ABSTRACT: Background/Objectives: In heme degradation, biliverdin reductase catalyzes the conversion of biliverdin to bilirubin. Defects in the biliverdin reductase A gene (BLVRA) causing biliverdinuria are extraordinarily rare in humans, and this inborn error of metabolism has not been reported in other mammals. The objective of this study was to diagnose biliverdinuria and identify the causal BLVRA variants in two adult mixed-breed dogs with life-long green urine. One of the dogs also had an unexplained regenerative anemia and mild hepatopathy. Methods: Clinicopathological evaluations, urinary mass spectroscopy, and molecular genetic studies were performed. Urine metabolic screening identified increased biliverdin concentrations in both cases relative to control dogs.

SUBMITTER: Furrow E 

PROVIDER: S-EPMC11675387 | biostudies-literature | 2024 Nov

REPOSITORIES: biostudies-literature