Is the Relationship Between Cardiovascular Disease and Alzheimer's Disease Genetic? A Scoping Review.

ABSTRACT:

Background/objectives

Cardiovascular disease (CVD) and Alzheimer's disease (AD) are two diseases highly prevalent in the aging population and often co-occur. The exact relationship between the two diseases is uncertain, though epidemiological studies have demonstrated that CVDs appear to increase the risk of AD and vice versa. This scoping review aims to examine the current identified overlapping genetics between CVDs and AD at the individual gene level and at the shared pathway level.

Methods

Following PRISMA-ScR guidelines for a scoping review, we searched the PubMed and Scopus databases from 1990 to October 2024 for articles that involved (1) CVDs, (2) AD, and (3) used statistical methods to parse genetic relationships.

Results

Our search yielded 2918 articles, of

SUBMITTER: Moore A 

PROVIDER: S-EPMC11675426 | biostudies-literature | 2024 Nov

REPOSITORIES: biostudies-literature