Various Hydrogel Types as a Potential In Vitro Angiogenesis Model.

ABSTRACT: Angiogenesis, the formation of new blood vessels, is a fundamental process in both physiological repair mechanisms and pathological conditions, including cancer and chronic inflammation. Hydrogels are commonly used as in vitro models to mimic the extracellular matrix (ECM) and support endothelial cell behavior during angiogenesis. Mesenchymal stem cells further augment cell and tissue growth and are therefore widely used in regenerative medicine. Here we examined the combination of distinct hydrogel types-fibrin, collagen, and human platelet lysate (HPL)-on the formation of capillaries in a co-culture system containing human umbilical vein endothelial cells (HUVECs) and bone marrow-derived mesenchymal stem cells (BM-MSCs). The mechanical properties and structural changes of the hydrogels w

SUBMITTER: Radermacher C 

PROVIDER: S-EPMC11675469 | biostudies-literature | 2024 Dec

REPOSITORIES: biostudies-literature