Reinforcement of Dextran Methacrylate-Based Hydrogel, Semi-IPN, and IPN with Multivalent Crosslinkers.

ABSTRACT: The need for new biomaterials to meet the needs of advanced healthcare therapies is constantly increasing. Polysaccharide-based matrices are considered extremely promising because of their biocompatibility and soft structure; however, their use is limited by their poor mechanical properties. In this light, a strategy for the reinforcement of dextran-based hydrogels and interpenetrated polymer networks (semi-IPNs and IPNs) is proposed, which will introduce multifunctional crosslinkers that can modify the network crosslinking density. Hydrogels were prepared via dextran methacrylation (DexMa), followed by UV photocrosslinking in the presence of diacrylate (NPGDA), triacrylate (TMPTA), and tetraacrylate (PETA) crosslinkers at different concentrations. The effect of these molecules was also te

SUBMITTER: Paoletti L 

PROVIDER: S-EPMC11675718 | biostudies-literature | 2024 Nov

REPOSITORIES: biostudies-literature