Optimized Extraction of Sargahydroquinoic Acid, Major Bioactive Substance, from <i>Sargassum yezoense</i> Using Response Surface Methodology.

ABSTRACT: Sargahydroquinoic acid (SHQA), a bioactive compound found in certain Sargassum species, exhibits significant health benefits. This study optimized the extraction of SHQA from Sargassum yezoense using response surface methodology (RSM) and evaluated its antioxidant effects through in vitro and in vivo assays. A Box-Behnken design (BBD) was effectively employed to investigate the effects of incubation temperature, time, and ethanol concentration on SHQA yield, achieving a high coefficient of determination (R² = 0.961). Analysis of variance (ANOVA) validated the model's reliability (F = 13.86, p = 0.005) and highlighted ethanol concentration as a highly significant factor (p < 0.001). Optimal extraction conditions were identified as 52.8 °C, 8.3 h

SUBMITTER: Baek S 

PROVIDER: S-EPMC11676218 | biostudies-literature | 2024 Dec

REPOSITORIES: biostudies-literature