Transcriptome of Kurthia gibsonii TYL-A1 Revealed the Biotransformation Mechanism of Tylosin.

ABSTRACT: Tylosin (TYL) pollution has aroused widespread concern, and its existence poses a serious threat to the environment and human health. Microbial degradation of antibiotics is considered to be an effective strategy to reduce the environmental impact of antibiotics, but its degradation mechanism is still unclear. In this study, transcriptome analysis was combined to explore the response mechanism of K. gibsonii strain TYL-A1 under TYL stress. The results showed that the strain showed a significant antioxidant response under TYL stress to cope with TYL-induced cell damage. TYL also increased the level of intracellular reactive oxygen species (ROS), damaged the integrity of the cell membrane, and inhibited the growth of strain TYL-A1. Transcriptome sequencing showed that under TYL exposu

SUBMITTER: Wang Y 

PROVIDER: S-EPMC11676290 | biostudies-literature | 2024 Dec

REPOSITORIES: biostudies-literature