Multifunctional SERS Chip for Biological Application Realized by Double Fano Resonance.

ABSTRACT: The in situ and label-free detection of molecular information in biological cells has always been a challenging problem due to the weak Raman signal of biological molecules. The use of various resonance nanostructures has significantly advanced Surface-enhanced Raman spectroscopy (SERS) in signal enhancement in recent years. However, biological cells are often immersed in different formulations of culture medium with varying refractive indexes and are highly sensitive to the temperature of the microenvironment. This necessitates that SERS meets the requirements of refractive index insensitivity, low thermal damage, broadband enhancement, and other needs in addition to signal enhancement. Here, we propose a SERS chip with integrated dual Fano resonance and the corresponding analytical model

SUBMITTER: Zhu W 

PROVIDER: S-EPMC11676296 | biostudies-literature | 2024 Dec

REPOSITORIES: biostudies-literature