A near-tight lower bound on the density of forward sampling schemes.

ABSTRACT:

Motivation

Sampling k-mers is a ubiquitous task in sequence analysis algorithms. Sampling schemes such as the often-used random minimizer scheme are particularly appealing as they guarantee at least one k-mer is selected out of every w consecutive k-mers. Sampling fewer k-mers often leads to an increase in efficiency of downstream methods. Thus, developing schemes that have low density, i.e. have a small proportion of sampled k-mers, is an active area of research. After over a decade of consistent efforts in both decreasing the density of practical schemes and increasing the lower bound on the best possible density, there is still a large gap between the two.

Results

We prove a near-tight lower bound on the density of forward sampling schemes, a class of schemes that general

SUBMITTER: Kille B 

PROVIDER: S-EPMC11676336 | biostudies-literature | 2024 Dec

REPOSITORIES: biostudies-literature