Effect of MCT1 A1470T Polymorphism on Lactate and Potassium Concentrations After Caffeine Ingestion During Acute Resistance Exercise.

ABSTRACT:

Background

The monocarboxylate transporter 1 (MCT1) plays a crucial role in regulating lactate and pyruvate transport across cell membranes, which is essential for energy metabolism during exercise. The MCT1 A1470T (rs1049434) polymorphism has been suggested to influence lactate transport, with the T (major) allele associated with greater transport efficiency. This study aimed to investigate the effect of the MCT1 polymorphism on lactate and potassium (K⁺) concentrations in response to resistance exercise (RE) following caffeine (CAF) ingestion.

Methods

Thirty resistance-trained athletes were randomly selected to participate in a randomized, double-blind, placebo-controlled crossover study. Participants consumed either CAF (6 mg/kg of body weight) or

SUBMITTER: Rahimi MR 

PROVIDER: S-EPMC11676378 | biostudies-literature | 2024 Dec

REPOSITORIES: biostudies-literature