Genomic Analysis and Functional Validation of Bidirectional Promoters in Medaka (Oryzias latipes).

ABSTRACT: Bidirectional promoters (BDPs) regulate the transcription of two adjacent, oppositely oriented genes, offering a compact structure with significant potential for multigene expression systems. Although BDPs are evolutionarily conserved, their regulatory roles and sequence characteristics vary across species, with limited studies in fish. Here, we systematically analyzed the distribution, sequence features, and expression patterns of BDPs in the medaka (Oryzias latipes) genome. A total of 1737 divergent gene pairs, representing 13% of medaka genes, were identified as potentially regulated by BDPs. These genes are enriched in essential biological processes, including organelle function, RNA processing, and ribosome biogenesis. Transcriptomic analysis revealed that co-regulation (co-exp

SUBMITTER: Liang J 

PROVIDER: S-EPMC11676430 | biostudies-literature | 2024 Dec

REPOSITORIES: biostudies-literature