Peripheral lncRNA NEAT-1, miR374b-5p, and IL6 panel to guide in COVID-19 patients' diagnosis and prognosis.

ABSTRACT:

Background

The SARS-CoV-2 virus's frequent mutations have made disease control with vaccines and antiviral drugs difficult; as a result, there is a need for more effective coronavirus drugs. Therefore, detecting the expression of various diagnostic biomarkers, including ncRNA in SARS-CoV2, implies new therapeutic strategies for the disease.

Aim

Our study aimed to measure NEAT-1, miR-374b-5p, and IL6 in the serum of COVID-19 patients, demonstrating the correlation between target genes to explore the possible relationship between them. Also, the association between target genes and patients' clinical findings and radiological severity indices will be explored.

Patients and methods

The current study included 48 COVID-19-infected individuals and 40 controls. Quantitative

SUBMITTER: Ali MA 

PROVIDER: S-EPMC11676515 | biostudies-literature | 2024

REPOSITORIES: biostudies-literature