Kanamycin and G-Quadruplexes: An Exploration of Binding Interactions.

ABSTRACT: G-quadruplexes (G4s) are distinctive four-stranded nucleic acid structures formed by guanine-rich sequences, making them attractive targets for drug repurposing efforts. Modulating their stability and function holds promise for treating diseases like cancer. To identify potential drug candidates capable of interacting with these complex DNA formations, docking studies and molecular dynamics (MDs) simulations were conducted. Our analysis revealed kanamycin's ability to bind to various G4 structures, offering valuable insights into its potential as a modulator of G4 activity. Kanamycin exhibited favorable interactions with both parallel and hybrid G4 topologies in human structures, suggesting a broader mechanism of action for aminoglycosides. These findings may also shed light on aminoglycos

SUBMITTER: Gualtieri G 

PROVIDER: S-EPMC11676551 | biostudies-literature | 2024 Dec

REPOSITORIES: biostudies-literature