Molecular matching tools for allocation and immunosuppression optimization. Ready for primetime?

ABSTRACT:

Purpose of review

Molecular matching continues to be an important topic in organ transplantation. Over the years, several studies - larger and smaller - supported correlations of molecular incompatibility loads and clinical outcomes. However, their practical utility for clinical decision making remains controversial and there is no consensus on the context in which they should be used.

Recent findings

The recent literature on molecular matching can be divided into four main areas of research: several groups present improvements of the algorithmic pipelines (1), increasing the robustness of previous findings. Further clinical evidence is reported (2) in various cohorts and other organ transplant domains, such as liver and lung transplantation. Consideration is given to the ap

SUBMITTER: Niemann M 

PROVIDER: S-EPMC11676598 | biostudies-literature | 2025 Feb

REPOSITORIES: biostudies-literature