The potential impact of new TB vaccines on the burden of TB in people living with HIV in South Africa.

ABSTRACT:

Background

People living with HIV (PLHIV) are at increased risk of tuberculosis (TB). New TB vaccines may help reduce this burden. New TB vaccine candidates are safe and immunogenic in PLHIV.There is currently limited data on vaccine efficacy in this population.

Methods

Using mathematical modelling we explored the potential impact of a novel TB vaccine on TB burden in PLHIV in South Africa between 2030-2050. We compared the impact of a vaccine delivered irrespective of HIV status to vaccination of either PLHIV or people without HIV. We explored the impact of reduced vaccine efficacy and duration of protection in PLHIV relative to people without HIV on our model predictions.

Results

Vaccination irrespective of HIV status, with a vaccine with equal efficacy and duration

SUBMITTER: Sumner T 

PROVIDER: S-EPMC11676631 | biostudies-literature | 2024 Oct

REPOSITORIES: biostudies-literature