Establishment of Novel High-Grade Serous Ovarian Carcinoma Cell Line OVAR79.

ABSTRACT: High-grade serous ovarian carcinoma (HGSOC) remains the most common and deadly form of ovarian cancer. However, available cell lines usually fail to appropriately represent its complex molecular and histological features. To overcome this drawback, we established OVAR79, a new cell line derived from the ascitic fluid of a patient with a diagnosis of HGSOC, which adds a unique set of properties to the study of ovarian cancer. In contrast to the common models, OVAR79 expresses TP53 without the common hotspot mutations and harbors the rare combination of mutations in both PIK3CA and PTEN genes, together with high-grade chromosomal instability with multiple gains and losses. These features, together with the high proliferation rate, ease of cultivation, and exceptional transfection effi

SUBMITTER: Shnaider PV 

PROVIDER: S-EPMC11676670 | biostudies-literature | 2024 Dec

REPOSITORIES: biostudies-literature