Early Diagnosis of Bloodstream Infections Using Serum Metabolomic Analysis.

ABSTRACT:

Background

Bloodstream infections (BSIs) pose a great challenge to treating patients, especially those with underlying diseases, such as immunodeficiency diseases. Early diagnosis helps to direct precise empirical antibiotic administration and proper clinical management. This study carried out a serum metabolomic analysis using blood specimens sampled from patients with a suspected infection whose routine culture results were later demonstrated to be positive.

Methods

A liquid chromatograph-mass spectrometry-based metabolomic analysis was carried out to profile the BSI serum samples. The serum metabolomics data could be used to successfully differentiate BSIs from non-BSIs.

Results

The major classes of the isolated pathogens (e.g., Gram-positive and Gram-negative bact

SUBMITTER: Han S 

PROVIDER: S-EPMC11676852 | biostudies-literature | 2024 Dec

REPOSITORIES: biostudies-literature