A Comprehensive Metabolomic and Microbial Analysis Following Dietary Amino Acid Reduction in Mice.

ABSTRACT: Introduction: Nutritional metabolomics provides a comprehensive overview of the biochemical processes that are induced by dietary intake through the measurement of metabolite profiles in biological samples. However, there is a lack of deep phenotypic analysis that shows how dietary interventions influence the metabolic state across multiple physiologic sites. Dietary amino acids have emerged as important nutrients for physiology and pathophysiology given their ability to impact cell metabolism. Methods: The aim of the current study is to evaluate the effect of modulating amino acids in diet on the metabolome and microbiome of mice. Here, we report a comprehensive metabolite profiling across serum, liver, and feces, in addition to gut microbial analyses, following a reduction

SUBMITTER: Al-Ishaq RK 

PROVIDER: S-EPMC11677231 | biostudies-literature | 2024 Dec

REPOSITORIES: biostudies-literature