Cytotoxic Effects of ZnO and Ag Nanoparticles Synthesized in Microalgae Extracts on PC12 Cells.

ABSTRACT: The green synthesis of silver (Ag) and zinc oxide (ZnO) nanoparticles (NPs), as well as Ag/Ag₂O/ZnO nanocomposites (NCs), using polar and apolar extracts of Chlorella vulgaris, offers a sustainable method for producing nanomaterials with tunable properties. The impact of the synthesis environment and the nanomaterials' characteristics on cytotoxicity was evaluated by examining reactive species production and their effects on mitochondrial bioenergetic functions. Cytotoxicity assays on PC12 cells, a cell line originated from a rat pheochromocytoma, an adrenal medulla tumor, demonstrated that Ag/Ag₂O NPs synthesized with apolar (Ag/Ag₂O NPs A) and polar (Ag/Ag₂O NPs P) extracts exhibited significant cytotoxic effects, primarily driven by Ag<

SUBMITTER: Fais G 

PROVIDER: S-EPMC11677574 | biostudies-literature | 2024 Dec

REPOSITORIES: biostudies-literature