Saliva Proteome, Metabolome and Microbiome Signatures for Detection of Alzheimer's Disease.

ABSTRACT: Background: As the burden of Alzheimer's disease (AD) escalates with an ageing population, the demand for early and accessible diagnostic methods becomes increasingly urgent. Saliva, with its non-invasive and cost-effective nature, presents a promising alternative to cerebrospinal fluid and plasma for biomarker discovery. Methods: In this study, we conducted a comprehensive multi-omics analysis of saliva samples (n = 20 mild cognitive impairment (MCI), n = 20 Alzheimer's disease and age- and n = 40 gender-matched cognitively normal individuals), from the South Australian Neurodegenerative Disease (SAND) cohort, integrating proteomics, metabolomics, and microbiome data with plasma measurements, including pTau181. Results: Among the most promising fi

SUBMITTER: Francois M 

PROVIDER: S-EPMC11677859 | biostudies-literature | 2024 Dec

REPOSITORIES: biostudies-literature