Role of the Anaphase-Promoting Complex Activator Cdh1 in the Virulence of <i>Cryptococcus neoformans</i>.

ABSTRACT: Cryptococcus neoformans is a globally distributed human fungal pathogen that can cause cryptococcal meningitis with high morbidity and mortality. In this study, we identified an anaphase-promoting complex (APC) activator, Cdh1, and examined its impact on the virulence of C. neoformans. Our subcellular localization analysis revealed that Cdh1 is situated in the nucleus of C. neoformans. Disrupting or overexpressing the CDH1 gene caused abnormal capsule formation in C. neoformans. The cdh1Δ mutant displayed slight sensitivity when grown at 37 °C, indicating that Cdh1 plays a role in maintaining the growth of C. neoformans at 37 °C. A fungal virulence assay showed that Cdh1 is closely associated with the virulence of C. neoformans, and b

SUBMITTER: Liao QH 

PROVIDER: S-EPMC11678062 | biostudies-literature | 2024 Dec

REPOSITORIES: biostudies-literature