Transcriptome Analysis Reveals Norathyriol Prolongs the Lifespan via Regulating Metabolism in <i>C. elegans</i>.

ABSTRACT:

Background

Aging and age-related diseases are closely linked to an imbalance in energy supply and demand, a condition that can potentially be mitigated through various interventions, including the use of naturally occurring molecules. Norathyriol (NL), a tetrahydroxyxanthone compound, is prevalent in mango fruit and medicinal plants. While studies have indicated that NL may influence metabolism, its effects on aging have not been extensively explored.

Methods

We conducted lifespan analysis and measured lipofuscin accumulation in C. elegans model to evaluate the effects of NL on aging. Additionally, we identified differentially expressed genes (DEGs) through comprehensive RNA-sequencing (RNA-seq) analysis and performed gene ontology (GO) and kyoto encyclopedia of genes

SUBMITTER: Zhang HJ 

PROVIDER: S-EPMC11678140 | biostudies-literature | 2024 Dec

REPOSITORIES: biostudies-literature