Natural Gomesin-like Peptides with More Selective Antifungal Activities.

ABSTRACT: Background: Antimicrobial peptides are generally considered promising drug candidates for combating resistant bacterial infections. However, the selectivity of their action may vary significantly. Natural gomesin, isolated from haemocytes of the tarantula Acanthoscurria gomesiana, demonstrates a broad spectrum of antimicrobial activities, being the most effective against pathogenic fungi. Methods: Here, we searched for variants of natural gomesin-like peptides and produced their recombinant analogs in the bacterial expression system. The antimicrobial activities of the obtained peptides were tested against a panel of bacterial and yeast strains, and their toxicity towards human cells was examined. Results: Most of the new analogs of gomesin have primary structur

SUBMITTER: Bolosov IA 

PROVIDER: S-EPMC11678162 | biostudies-literature | 2024 Dec

REPOSITORIES: biostudies-literature