Virus-like Particles Produced in Plants: A Promising Platform for Recombinant Vaccine Development.

ABSTRACT: The capsid proteins of many viruses are capable of spontaneous self-assembly into virus-like particles (VLPs), which do not contain the viral genome and are therefore not infectious. VLPs are structurally similar to their parent viruses and are therefore effectively recognized by the immune system and can induce strong humoral and cellular immune responses. The structural features of VLPs make them an attractive platform for the development of potential vaccines and diagnostic tools. Chimeric VLPs can be obtained by attaching foreign peptides to capsid proteins. Chimeric VLPs present multiple copies of the antigen on their surface, thereby increasing the effectiveness of the immune response. Recombinant VLPs can be produced in different expression systems. Plants are promising biofactories

SUBMITTER: Mardanova ES 

PROVIDER: S-EPMC11678810 | biostudies-literature | 2024 Dec

REPOSITORIES: biostudies-literature