Novel Quinoline- and Naphthalene-Incorporated Hydrazineylidene-Propenamide Analogues as Antidiabetic Agents: Design, Synthesis, and Computational Studies.

ABSTRACT: Background: Type 2 diabetes has become a significant global health challenge. Numerous drugs have been developed to treat the condition, either as standalone therapies or in combination when glycemic control cannot be achieved with a single medication. As existing treatments often come with limitations, there is an increasing focus on creating novel therapeutic agents that offer greater efficacy and fewer side effects to better address this widespread issue. Methods: The methylene derivatives 3a,b were coupled with phenyl/ethyl isothiocyanate in the basic medium, and dimethyl sulfate was subsequently added. Further, 5a-d were reacted with the quinoline/naphthalene hydrazides 6a,b. The target compounds 7a-g were subjected

SUBMITTER: Alharbi O 

PROVIDER: S-EPMC11679724 | biostudies-literature | 2024 Dec

REPOSITORIES: biostudies-literature