Association of Metabolic Diseases and Moderate Fat Intake with Myocardial Infarction Risk.

ABSTRACT:

Background

Myocardial infarction (MI) can range from mild to severe cardiovascular events and typically develops through complex interactions between genetic and lifestyle factors.

Objectives

We aimed to understand the genetic predisposition associated with MI through genetic correlation, colocalization analysis, and cells' gene expression values to develop more effective prevention and treatment strategies to reduce its burden.

Methods

A polygenic risk score (PRS) was employed to estimate the genetic risk for MI and to analyze the dietary interactions with PRS that affect MI risk in adults over 45 years (n = 58,701). Genetic correlation (rg) between MI and metabolic syndrome-related traits was estimated with linkage disequilibrium score regression. Single-cell

SUBMITTER: Zhou J 

PROVIDER: S-EPMC11679910 | biostudies-literature | 2024 Dec

REPOSITORIES: biostudies-literature