Genomic Evolution of the SARS-CoV-2 Omicron Variant in Cordoba, Argentina (2021-2022): Analysis of Uncommon and Prevalent Spike Mutations.

ABSTRACT: Understanding the evolutionary patterns and geographic spread of SARS-CoV-2 variants, particularly Omicron, is essential for effective public health responses. This study focused on the genomic analysis of the Omicron variant in Cordoba, Argentina from 2021 to 2022. Phylogenetic analysis revealed the dominant presence of BA.1 and BA.2 lineages, with BA.5 emerging earlier than BA.4, aligning with observations from other regions. Haplotype network analysis showed significant genetic divergence within Omicron samples, forming distinct clusters. In comparison to global datasets, we identified mutations in the Omicron genomes (A27S, Y145D, and L212I) situated within the NTD region of the Spike protein. These mutations, while not widespread globally, showed higher prevalence in our region. Of pa

SUBMITTER: Olivero NB 

PROVIDER: S-EPMC11680156 | biostudies-literature | 2024 Dec

REPOSITORIES: biostudies-literature