Genome Analysis of Anti-Phage Defense Systems and Defense Islands in <i>Stenotrophomonas maltophilia</i>: Preservation and Variability.

ABSTRACT: Anti-phage defense systems are widespread in bacteria due to the latter continuous adaptation to infection by bacteriophages (phages). Stenotrophomonas maltophilia has a high degree of intrinsic antibiotic resistance, which makes phage therapy relevant for the treatment of infections caused by this species. Studying the array of anti-phage defense systems that could be found in S. maltophilia helps in better adapting the phages to the systems present in the pathogenic bacteria. Pangenome analysis of the available S. maltophilia strains with complete genomes that were downloaded from GenBank, including five local genomes, indicated a wide set of 72 defense systems and subsystems that varied between the strains. Seven of these systems were present in more than 20% of the

SUBMITTER: Jdeed G 

PROVIDER: S-EPMC11680222 | biostudies-literature | 2024 Dec

REPOSITORIES: biostudies-literature