Innate Immune Response Against Batai Virus, Bunyamwera Virus, and Their Reassortants.

ABSTRACT: Orthobunyaviruses (OBVs) represent a diverse group of RNA viruses, encompassing a progressively increasing number of arboviruses that cause disease in both humans and livestock. Yet, studies investigating these viruses remain scarce despite the critical importance of such knowledge for assessing their zoonotic potential. In this study, we conducted an evaluation of the early immune response against the understudied Batai virus (BATV), as well as the influence of reassortment with the Bunyamwera virus (BUNV) on this response. Using RNA sequencing of infected murine bone marrow-derived dendritic cells, complemented by qPCR assays, we assessed the innate immune response at the transcriptome level. Additionally, we extended the qPCR analysis by including human THP-1-derived dendritic ce

SUBMITTER: Zoller DDJA 

PROVIDER: S-EPMC11680289 | biostudies-literature | 2024 Nov

REPOSITORIES: biostudies-literature