T Cell Responses to BA.2.86 and JN.1 SARS-CoV-2 Variants in Elderly Subjects.

ABSTRACT:

Background/objectives

New SARS-CoV-2 variants are continuously emerging, making it essential to assess the efficacy of vaccine-induced immune protection. Limited information is available regarding T cell responses to BA.2.86 and JN.1 variants, particularly in elderly individuals.

Methods

We evaluated T cell and total IgG responses against the receptor-binding domain (RBD) of the ancestral SARS-CoV-2 strain, as well as BA.2.86 and JN.1 omicron subvariants, in two groups of subjects. One group consisted of SARS-CoV-2-exposed elderly individuals who were fully vaccinated with the BNT162B2 mRNA vaccine, with a booster dose of the updated 2023-2024 COVID-19 vaccine (XBB.1.5) at least 15 days after receiving a booster dose of the updated 2023-2024 COVID-19 vaccine. The second grou

SUBMITTER: Segato I 

PROVIDER: S-EPMC11680353 | biostudies-literature | 2024 Dec

REPOSITORIES: biostudies-literature