Tissue-Specific DNA Methylation Changes in CD8⁺ T Cells During Chronic Simian Immunodeficiency Virus Infection of Infant Rhesus Macaques.

ABSTRACT: Robust CD8⁺ T cell responses are critical for the control of HIV infection in both adults and children. Our understanding of the mechanisms driving these responses is based largely on studies of cells circulating in peripheral blood in adults, but the regulation of CD8⁺ T cell responses in tissue sites is poorly understood, particularly in pediatric infections. DNA methylation is an epigenetic modification that regulates gene transcription. Hypermethylated gene promoters are associated with transcriptional silencing and, conversely, hypomethylated promoters indicate gene activation. In this study, we evaluated DNA methylation signatures of CD8⁺ T cells isolated from several different anatomic compartments during pediatric AIDS-virus infection by utilizing t

SUBMITTER: Nag M 

PROVIDER: S-EPMC11680437 | biostudies-literature | 2024 Nov

REPOSITORIES: biostudies-literature