A novel piglet model of esophageal stricture following variable segmental esophageal resection and re-anastomosis.

ABSTRACT:

Background

Esophageal strictures following esophageal atresia repair are a source of significant morbidity. To test new therapeutic approaches, we designed a piglet model of esophageal stricture by resecting variable lengths of esophagus with subsequent re-anastomosis. This study describes the model and validates its physiologic impact by blinded analysis of the weight gains of the piglets.

Methods

A total of 24 two-week old Pietrain piglets had esophageal resections performed, ranging from 0 to 5 cm, with the goal of inducing postoperative esophageal strictures. Postoperative body-weights were evaluated by repeated analysis of variance followed by pairwise group-comparisons based on estimated marginal means. In addition, body weight was modeled by linear-mixed model regress

SUBMITTER: von Sochaczewski CO 

PROVIDER: S-EPMC11680478 | biostudies-literature | 2024 Dec

REPOSITORIES: biostudies-literature