Biodistribution and dosimetry of the PET radioligand [¹⁸F]CHDI-650 in mice for detection of mutant huntingtin aggregates.

ABSTRACT:

Background

Huntington's disease (HD) is a rare neurodegenerative disorder caused by an expansion of the CAG trinucleotide repeat in the huntingtin gene which encodes the mutant huntingtin protein (mHTT) that is associated with HD-related neuropathophysiology. Noninvasive visualization of mHTT aggregates in the brain, with positron emission tomography (PET), will allow to reliably evaluate the efficacy of therapeutic interventions in HD. This study aimed to assess the radiation burden of [¹⁸F]CHDI-650, a novel fluorinated mHTT radioligand, in humans based on both in vivo and ex vivo biodistribution in mice and subsequent determination of dosimetry for dosing in humans.

Results

Wild-type male and female CD-1 Swiss mice (n = 15/sex) were used to assess in vivo PET im

SUBMITTER: Akkermans J 

PROVIDER: S-EPMC11680546 | biostudies-literature | 2024 Dec

REPOSITORIES: biostudies-literature