Constitutive androstane receptor (CAR) functions as a tumor suppressor via regulating stemness in liver cancer.

ABSTRACT: Constitutive androstane receptor (CAR) is a xenosensor that is almost exclusively expressed in the liver. Studies in rodents suggest an oncogenic role for CAR in liver cancer, but its role in human liver cancer is unclear. We aimed to investigate the functional roles of CAR in human liver cancer with a focus on the liver cancer stem cells. We used bioinformatics to increase our understanding of CAR in human liver cancer and associated stem cell markers. We studied the functional roles of CAR in human liver cancer with a focus on the liver cancer stem cell using siRNA, modulation of CAR activity, and tumorsphere formation assays. We have revealed significant associations between CAR and a wide variety of signalling pathways including stemness signalling. Further in vitro studies have shown

SUBMITTER: Bae SDW 

PROVIDER: S-EPMC11680565 | biostudies-literature | 2024 Dec

REPOSITORIES: biostudies-literature