Spinally targeted paired associated stimulation with high-frequency peripheral component induces spinal level plasticity in healthy subjects.

ABSTRACT: A novel variant of paired-associative stimulation (PAS) consisting of high-frequency peripheral nerve stimulation (PNS) and high-intensity transcranial magnetic stimulation (TMS) above the motor cortex, called high-PAS, can lead to improved motor function in patients with incomplete spinal cord injury. In PAS, the interstimulus interval (ISI) between the PNS and TMS pulses plays a significant role in the location of the intended effect of the induced plastic changes. While conventional PAS protocols (single TMS pulse often applied with intensity close to resting motor threshold, and single PNS pulse) usually require precisely defined ISIs, high-PAS can induce plasticity at a wide range of ISIs and also in spite of small ISI errors, which is helpful in clinical settings where precise ISI de

SUBMITTER: Natkynmaki A 

PROVIDER: S-EPMC11680591 | biostudies-literature | 2024 Dec

REPOSITORIES: biostudies-literature