Diffusion-derived intravoxel-incoherent motion anisotropy relates to CSF and blood flow.

ABSTRACT: This study investigates the feasibility of multi-b-value, multi-directional diffusion MRI for assessing the anisotropy of the cerebral pseudo-diffusion (D*)-tensor. We examine D*-tensor's potential to (1) reflect CSF and blood flow, and (2) detect microvascular architectural alterations in cerebral small vessel disease (cSVD) and aging.

Methods

Multi-b-value diffusion MRI was acquired in 32 gradient directions for 11 healthy volunteers, and in six directions for 29 patients with cSVD and 14 controls at 3 T. A physics-informed neural network was used to estimate intravoxel incoherent motion (IVIM)-DTI model parameters, including the parenchymal slow diffusion (D-)tensor and the pseudo-diffusion (D*)-tensor, from which the fractional anisotropy (FA), mean diffusivity (MD), axial diffu

SUBMITTER: Voorter PHM 

PROVIDER: S-EPMC11680721 | biostudies-literature | 2025 Mar

REPOSITORIES: biostudies-literature