Chronic unpredictable stress induces anxiety-like behavior and oxidative stress, leading to diminished ovarian reserve.

ABSTRACT: Chronic stress can adversely affect the female reproductive endocrine system, potentially leading to disorders and impairments in ovarian function. However, current research lacks comprehensive understanding regarding the biochemical characteristics and underlying mechanisms of ovarian damage induced by chronic stress. We established a stable chronic unpredictable stress (CUS)-induced diminished ovarian reserve (DOR) animal model. Our findings demonstrated that prolonged CUS treatment over eight weeks resulted in increased atresia follicles in female mice. This atresia was accompanied by decreased AMH and increased FSH levels. Furthermore, we observed elevated levels of corticosterone both in the peripheral blood and within the ovary. Additionally, we detected abnormalities in ATP metaboli

SUBMITTER: Zhou Z 

PROVIDER: S-EPMC11680781 | biostudies-literature | 2024 Dec

REPOSITORIES: biostudies-literature