Identification of Anoikis-related potential biomarkers and therapeutic drugs in chronic thromboembolic pulmonary hypertension via bioinformatics analysis and in vitro experiment.

ABSTRACT: There is growing evidence that programmed cell death plays a significant role in the pathogenesis of chronic thromboembolic pulmonary hypertension (CTEPH). Anoikis is a newly discovered type of programmed death and has garnered great attention. However, the precise involvement of Anoikis in the progression of CTEPH remains poorly understood. The goal of this study was to identify Anoikis-related genes (ARGs) and explore potential therapeutic drugs for CTEPH. Differentially expressed genes were identified by limma and weighted gene co-expression network analysis (WGCNA) packages, and functional analyses were conducted based on the differentially expressed genes. Subsequently, a combination of protein-protein interaction (PPI), Least Absolute Shrinkage and Selection Operator (LASSO), and Sup

SUBMITTER: Yu H 

PROVIDER: S-EPMC11680802 | biostudies-literature | 2024 Dec

REPOSITORIES: biostudies-literature