A novel biomarker of COVI-19: MMP8 emerged by integrated bulk RNAseq and single-cell sequencing.

ABSTRACT: COVID-19 has been emerging as the most influential illness which has caused great costs to the heath of population and social economy. Sivelestat sodium (SS) is indicated as an effective cure for lung dysfunction, a characteristic symptom of COVID-19 infection, but its pharmacological target is still unclear. Therefore, a deep understanding of the pathological progression and molecular alteration is an urgent issue for settling the diagnosis and therapy problems of COVID-19. In this study, the bulk ribonucleic acid sequencing (RNA-seq) data of healthy donors and non-severe and severe COVID-19 patients were collected. Then, target differentially expressed genes (DEGs) were screened through integrating sequencing data and the pharmacological database. Besides, with the help of functional and

SUBMITTER: Liu Z 

PROVIDER: S-EPMC11680813 | biostudies-literature | 2024 Dec

REPOSITORIES: biostudies-literature