An ultra low frequency spike timing dependent plasticity based approach for reducing alcohol drinking.

ABSTRACT: Alcohol use disorder (AUD) is a chronic relapsing brain disorder characterized by an impaired ability to stop or control alcohol consumption despite adverse social, occupational, or health consequences. AUD affects nearly one-third of adults at some point during their lives, with an associated cost of approximately $249 billion annually in the U.S. alone. The effects of alcohol consumption are expected to increase significantly during the COVID-19 pandemic, with alcohol sales increasing by approximately 54%, potentially exacerbating health concerns and risk-taking behaviors. Unfortunately, existing pharmacological and behavioral therapies for AUD are associated with poor success rates, with approximately 40% of individuals relapsing within three years of treatment.Pre-clinical studies have

SUBMITTER: Asp AJ 

PROVIDER: S-EPMC11680995 | biostudies-literature | 2024 Dec

REPOSITORIES: biostudies-literature