Omics-based analysis of mitochondrial dysfunction and BBB integrity in post-COVID-19 sequelae.

ABSTRACT: The SARS-CoV-2 virus that resulted in the COVID-19 pandemic has been implicated in a range of neurological issues, such as encephalopathy, stroke, and cognitive decline. Although the precise mechanism causing these issues is unknown, mounting evidence shows that blood-brain barrier (BBB) disruption is probable2 a major factor. The integrity of the blood-brain barrier (BBB), a highly selective barrier that divides the brain from the systemic circulation, is crucial for preserving normal brain function. By analysing the multi-transcriptome data, this work explores the neurological impacts of the SARS-CoV-2 virus and provides insight into the molecular mechanisms behind BBB breakdown and neurological symptoms in COVID-19 patients. The endothelial cells of BBB expresses inflammatory genes in r

SUBMITTER: Dhariwal R 

PROVIDER: S-EPMC11681072 | biostudies-literature | 2024 Dec

REPOSITORIES: biostudies-literature