Koala MHCII association with chlamydia infertility remains equivocal: a need for new research approaches.

ABSTRACT: Chlamydiosis is a common infectious disease impacting koalas and is a major cause of population decline due to resulting mortality and infertility. Polymorphisms of major histocompatibility complex (MHC) genes influence chlamydial disease outcomes in several species but koala studies have produced variable results. We aimed to identify the MHC II DAB and DBB repertoire of koalas from Liverpool Plains, NSW, a population heavily impacted by chlamydiosis. We compared variants between two studies, age cohorts and chlamydial infertility groups. Four DBB and eight DAB alleles were identified. The mean number of DAB alleles per individual increased and allele frequencies differed relative to a previous study, however the mean number of DBB alleles per individual decreased generationally, between

SUBMITTER: Kidd A 

PROVIDER: S-EPMC11681110 | biostudies-literature | 2024 Dec

REPOSITORIES: biostudies-literature